BIOL 360 – Neuroplasticity and Neurogenesis in Health and Disease: Molecules, Cells, and Circuits

This course will examine structural and functional neuroplasticity in the nervous system. The ability of the nervous system to reorganize itself by forming new connections, strengthening existing connections, or pruning away old synaptic connections is regulated by our environment, both within the body and the external world. We’ll examine critical periods in development when sensory experiences change and sculpt the wiring of the brain, learn how the birth of new neurons changes across the lifespan, and discover how adult neurogenesis is altered by the aging process, physical exercise, stress, and neuropsychiatric disorders, such as epilepsy and Alzheimer’s disease. We’ll also learn about potential stem cell therapies for enhancing brain repair and plasticity after brain injuries. Students will prepare for class by reading scientific papers and reviews on the topic. In class, I will introduce the topic with slide presentations, and after that we will discuss the topic based on the scientific article discussion. After the classes students will have extensive opportunities for feedback and will be requested to write a simple paragraph for the next class and/or answer a small quiz, based on the new knowledge acquired. Student evaluation will include weekly quizzes and/or assessment, a final exam, and class participation.